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This suggests that systemic endothelial dysfunction may be a primary factor in the development of systemic hypertension and its pathological consequences, such as increased left ventricular wall stress, hypertrophy, diastolic dysfunction, and HFpEF [22]

Periorbital puffiness, the slight swelling around the eyes that accompanies inflammation and excess weight, resolves as systemic inflammation decreases

TGR5 ligands improve insulin sensitivity and glucose homeostasis through the secretion of incretins (27) and the rapid improvement of hyperglycemia after bariatric surgery has been attributed partly to alterations in bile acid metabolism and sensing (29, 30)

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