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Besides, suppressing of IGF1R both leads to ATM kinase inactivation and inhibited DNA-PKcs phosphorylation, which are involved in the DNA repair of NHEJ (Chitnis et al., 2014)

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Tirzepatide, having received FDA approval, has a more defined safety record, though patients should be monitored for potential risks such as pancreatitis or thyroid tumors, which have been concerns with GLP-1 receptor agonists in general

0.2 g.kg 1 BM