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Semaglutide, a glucagon like peptide-1 receptor agonist with cardiovascular benefits for management of type 2 diabetes Polycystic Ovary Syndrome Obesity Classification Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility The Role of Polycystic Ovary Syndrome in Reproductive and Metabolic Health: Overview and Approaches for Treatment Why are women with polycystic ovary syndrome obese

Most doctors will recommend that candidates try other weight management approaches first before prescribing GLP-1 therapy

Ethics declarations Acknowledgements The authors wish to thank Kylie Lange (Centre of Research Excellence in Translating Nutritional Science into Good Health, The University of Adelaide, Australia) for her expert statistical advice, and Scott Standfield and Judith Wishart (Centre of Research Excellence in Translating Nutritional Science into Good Health, The University of Adelaide, Australia) for performing the GLP-1 and insulin assays

doi: 10.1056/NEJMoa2206038 12 le RouxCWSteenOLucasKJStartsevaEUnseldAHennigeAM