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The consistency of GLP-1 effectiveness across alcohol, opioids, cocaine, nicotine, and cannabis suggests these drugs may act on a shared vulnerability underlying addiction not on any single substance pathway

On the other hand, peripheral administration of pharmacological doses of exogenous radiolabelled GLP1 leads to detectable amounts found in the circumventricular organs of the brain, which are characterised by a leaky bloodbrain barrier (BBB) (Orskov et al., 1996)

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As metabolic health improves with weight loss and better glycemic control, some of these conditions may improve, potentially enhancing sexual health