semaglutide and niacinamide together Ivím Health Tirzepatide / Niacinamide – WP

Its serendipitous discovery as a weight-loss aid mirrors bariatric surgery, which is founded on the finding that patients undergoing stomach (gastric) surgery in the 50s for ulcer disease all lost weight

It took me a while to wrap my head around all this

In LKB1-deficient non-small cell lung cancer (NSCLC) models, AMPK inactivation derepresses CPS1, whose silencing induces nucleotide pool imbalance (reduced pyrimidine/purine ratio), S-phase arrest, and DNA damage, mechanisms hypothesized to operate in PCa, where ammonium metabolism inhibitors (e.g., targeting glutaminase) combined with autophagy modulators (e.g., ULK1 activators) could exploit metabolic vulnerabilities targeting tumor cells (200)