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Post-alkali injury, TB-500 exposure is believed to possibly reduce the levels of chemoattractants like macrophage inflammatory protein-2 (MIP-2) and keratinocyte chemoattractant (KC), which may lead to a reduction in polymorphonuclear neutrophils (PMNs) infiltration

adjacent compounds

Studies on athletes show whole-body cryotherapy reduces circulating levels of the pro-inflammatory cytokine IL-1 beta while increasing the anti-inflammatory cytokine IL-10 and the cytokine inhibitor IL-1 receptor antagonist (IL-1ra)

Hypoxia at the injury site resolves faster with improved perfusion, removing the oxygen-deficit barrier to fibroblast metabolism