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Even better outcomes are seen with surgical procedures like the gastric sleeve, which yield up to 5x the weight loss than even the most powerful GLP-1

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For example: Tirzepatide (Zepbound) shows the greatest mean weight loss and is also approved for obstructive sleep apnea, but semaglutide (Wegovy) is preferred for those with cardiovascular or kidney complications or metabolic-associated steatohepatitis (MASH) due to broader FDA approvals