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Oxidative stress occurs when there is an imbalance between free radicals (unstable atoms that can damage cells) and antioxidants

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doi: 10.3389/fimmu.2025.1687755 Received 18 August 2025 Revised 26 October 2025 Accepted 17 November 2025 Published 16 December 2025 Volume 16 - 2025 Edited by Karina Pino-Lagos, University of the Andes, Chile Reviewed by Jaxaira Maggi, Spanish National Research Council (CSIC), Spain Noymar Luque-Campos, INSERM U1183 Institut de Mdecine Rgnratrice et de Biothrapie (IRMB), France Updates Copyright 2025 Hu, Zhao, Dai, Wu, Tang, Zhang, Jiang, Rui and Liu

Quality sleep is vital for proper cellular function, and lack of sleep on a regular basis is a chronic mild stressor.[ref] Related article : Circadian rhythm and mood disorders The body is made to handle short-term stress well