molecular hydrogen nrf2 glutathione

molecular hydrogen nrf2 glutathione protects against oxidative stress-induced RAW 264.7 macrophage cells through the activation of and inhibition of MAPK signaling pathway | Molecular & Cellular Toxicology Roles of Oxidative Stress and

Name: molecular hydrogen nrf2 glutathione protects against oxidative stress-induced RAW 264.7 macrophage cells through the activation of and inhibition of MAPK signaling pathway | Molecular & Cellular Toxicology Roles of Oxidative Stress and
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Description

S-glutathionylation has been shown to regulate the activity of numerous transcription factors and signaling proteins, including those in the NF-B, AP-1, and MAP kinase pathways (e.g., JNK, p38)

doi: 10.1016/j.diabres.2020.108120 69

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As IKK- is the direct upstream kinase that phosphorylates IB-, leading to its degradation, we next examined whether decreased TNF-induced IB- phosphorylation by H 2 O 2 treatment was due to its effects on IKK- activity