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most individuals had a BMI 40 kg/m 2

Recommended Vial Size by Protocol Beginners (0.5-1mg/week): Start with a 5mg or 10mg vial tests tolerance without large upfront cost A 5mg vial at 0.5mg/week = 10 weeks, well beyond 28 days but manageable with proper storage Standard protocols (1-2mg/week): 12mg vial offers the best balance of value and practicality Buy multiple 12mg vials rather than one large vial for better freshness Higher doses (4mg+/week): 24mg or 60mg vials make economic sense At 4mg/week, a 24mg vial lasts 6 weeks close to the 28-day window Buying Multiple Smaller vs One Large Vial Our recommendation: For most users, buying 2-3 vials of 12mg offers the best balance of value, freshness, and flexibility

Any trial off therapy should be clinician-guided with alternative supports in place, as medication pauses typically lead to weight regain without a comprehensive plan

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