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SGLT2 inhibitors when used as an add-on therapy to metformin, insulin, thiazolidinediones, DPP-4 inhibitors, GLP-1 RAs, sulfonylureas, or metformin DPP-4 inhibitor were similarly effective in reducing A1c levels as when used in monotherapy (22,139)

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Glycine was found to improve performance on memory, cognition, and reaction-time tests and self-rated fatigue and sleepiness levels compared with placebo