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Beyond GI effects, patients should watch for: Headaches , particularly during the first two weeks and after dose escalations Insomnia or sleep disruption, which affects some patients more than others Muscle pain and body aches , often reported in the first week of a new dose Anxiety , which some patients experience as appetite suppression creates unfamiliar hunger signals Joint pain , reported less frequently but worth monitoring Injection site reactions , including redness, itching, and localized swelling Menstrual changes , as rapid weight loss and hormonal shifts can affect cycle regularity Fatigue , especially during the caloric restriction phase Hair loss , a known but usually temporary effect of significant weight loss If side effects become unmanageable at any dose, the microdose tirzepatide schedule offers an alternative approach

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Consider other antidiabetic therapies in patients with a history of pancreatitis