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Description

The Delphi panel did not support the use of agents that increase meal viscosity or diazoxide (statements 48 and 52)

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2009;4:e6744

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MIN6 and Figure 4

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This temporal pattern is consistent with the well-described phenomenon of GI adaptation to GLP-1 receptor activation, in which chronic receptor stimulation leads to desensitization of the vagal afferent pathways that mediate nausea and the enteric nervous system circuits that regulate gastric emptying and motility

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