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HBOT-induced ROS production enhances angiogenic potential and growth factor expression in mesenchymal stem cells, whereas NAC significantly diminishes these responses ( In contrast, under conditions marked by substantially elevated baseline oxidative stress, combined NAC and HBOT may provide additional therapeutic advantages ( Importantly, clinical evidence remains extremely limited

J., Ameer

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A first mechanism is the direct interaction with the reducing thiolate, leading to irreversible inactivation of the active site, as described for the inactivation of GSTs (Scheme 9)