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However, in contrast to these findings, a more recent large-scale randomized trial found no differences in the number of chronic obstructive pulmonary disease exacerbations per year or the yearly rate of decline in the forced expiratory volume in one second when 600 mg of N -acetylcysteine was taken orally once daily (63)

MPTP and SNpc DA neuronal vulnerability: role of dopamine, superoxide and nitric oxide in neurotoxicity

1994 May-Jun;26(3):155-9

As we have discussed in earlier rulemaking, in connection with the use of this authority for establishing the program's ( participation options (see 76 FR 67904 through 67909, 80 FR 32771 and 32772, 83 FR 67834 through 67841), the program's two-sided models provide an additional opportunity for ACOs to enter a risk-sharing arrangement and accept greater responsibility for beneficiary care