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A 2026 preprint covering 7,965 individuals found people on tirzepatide (Mounjaro, Zepbound) lost approximately 1.1% to 2% more lean body mass than people on semaglutide (Ozempic, Wegovy) over 12 months, though the authors acknowledged the study was not yet peer-reviewed at time of analysis

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Similarly, women with PCOS are more likely to have obesity and trouble conceiving than other women because of hormonal imbalances that cause irregular menstrual cycles

This study was part of the Semaglutide Treatment Effect in People with Obesity (STEP) clinical trial program