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Mittendorf EA, Lu B, Melisko M, Hiller JP, Bondarenko I, Brunt AM, et al

These findings elucidated a positive DSIP effect on the recovery of motor performance after stroke

At neutral to alkaline pH (above 7), deamidation proceeds through a cyclic imide intermediate that produces a mixture of normal and isomerized products

For example, the neurotoxin models of PD (using MPTP or 6-OHDA) recapitulate features of the diseaseelevated -synuclein, astrocyte activation, bloodbrain barrier disruption, inflammation, oxidative stress, and dopaminergic neuron lossand these models have demonstrated the neuroprotective potential of various dietary polyphenols (10)