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In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]

Advanced purification systems, including continuous chromatography, offer improved process productivity and scalability, which are vital for the commercial manufacturing of these biologics

That does not mean every online pathway is automatically unsafe

Think of it as the third lever