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*Correspondence: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
In addition to the regulation of this main transcription loop, CLOCK/BMAL1 stimulates the expression of other clock-related transcriptions, such as REV-ERB , retinoic acid-borne orphaned binders a ( ROR ), DEC1 , DEC2 , and albumin D-binding ( DBP ), which form an auxiliary loop that stabilizes the main regulatory loop (Ripperger and Schibler, 2006
Zhang Q, Delessa CT, Augustin R, Bakhti M, Colldn G, Drucker DJ, et al
Kaplan-Meier survival analysis confirmed that high L1-ATP8B1 expression was significantly associated with poor overall survival in LUSC samples (Fig
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