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Semaglutide is a peptide it mimics natural GLP-1 and binds at the receptor's main docking site (the orthosteric site, at the top)

8a edio Si Z, Wang X (2020) The neuroprotective and Neurodegeneration effects of Heme Oxygenase-1 in Alzheimers Disease

These findings do not mean that every patient has a primary mitochondrial disease

While as little as 1 gram of L-carnitine can be effective, your best bet is to take 2-3 grams per dose for maximum benefit, along with at least 30-40 grams of carbs and 20-40 grams of protein, preferably with a meal