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doi: 10.1016/j.neuroimage.2016.02.015, 49 KuoM

It activates the PKC signaling pathway, leading to ERK1/2 activation, which ultimately activates mTOR and promotes epithelial cell proliferation, an effect that can be blocked by rapamycin, an mTOR inhibitor (103), indicating the involvement of mTOR in the proliferation of ectopic endometrial cells

HMB is known to possibly increase protein synthesis and support muscle retention during weight loss but the data on that one is really inconclusive and in my opinion does not really justify HMB use

The genetic instability ulteriorly leads to genetic alterations in cells, such as somatic mutations of PIK3CA and TP53 , which are non-inherited