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Second, we repeated the analytic approach from our primary analysis, restricted to the following subgroups: (1) subjects whose follow-up period began no earlier than January 2013 (ie, when SGLT-2 inhibitors were introduced to the US market), and (2) adherent subjects who, during at least the first 6 months of follow-up, used no other diabetes medications (besides metformin and the index medication) and filled prescriptions for the index medication for at least 80% of included days supply

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