Radiation-induced bystander effect (RIBE), which was found in the 1990s, challenged the conventional dogma that no effects were expected in the cell population that had not been exposed to radiation
Therefore, treatment with GLP-1RAs shows favorable effects on anti-inflammation through the suppression of these proinflammatory cytokine and inflammatory signal pathways, as well as augmenting cholesterol efflux in the endothelium
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One proposed mechanism is that SNAC temporarily associates with drug molecules, increasing their lipophilicity and making it easier for them to cross biological membranes
