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Funding The research was supported by the Medical Scientific Research Foundation of Guangdong Province (B2024013), the Guangdong Basic and Applied Basic Research Foundation (2023A1515111083) to Songshan Li, the Major scientific and technological projects of Guangdong Province (2023B1111050008), Science and Technology Innovation Project of Guangdong Provincial Drug Administration (2022ZDZ08) to Shuwen Liu, Nanfang Hospital Baiyun Branch Presidents Fund (BYYZ23014) to Minghan Li, and Guangzhou Science and Technology Project Fund (2023A04J1831) to Aijiao Yu

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