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McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bhm M, Burri H, Butler J, elutkien J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A, ESC Scientific Document Group

Collectively, astrocytic state transitions and the resulting heterogeneity enables glial networks to flexibly sustain neuronal activity and preserve circuit homeostasis

Big data is great, but large n doesn't shield you from the many biases that can result from electronic health records and all the confounders from time and patient-doctor relationships