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Adipocyte Hypertrophy, Inflammation, and Insulin Resistance In the context of obesity and T2DM, adipose tissue expansion is often dominated by adipocyte hypertrophy rather than healthy hyperplasia, leading to reduced lipid storage capacity and increased lipotoxic exposure of peripheral organs such as the liver and skeletal muscle (Figure 1) [15]

Nomenclature of targets and ligands Key protein targets and ligands in this article are hyperlinked to corresponding entries in the IUPHAR/BPS Guide to PHARMACOLOGY ( and are permanently archived in the Concise Guide to PHARMACOLOGY 2019/20 (Alexander, Christopoulos, et al., 2019

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