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Direct answer: Mild digestive symptoms like nausea, constipation, or bloating may continue but often improve in severity

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Lastly, weight gain is common with sulfonylurea and insulin therapy, whereas GLP-1 analogs induce weight loss and offset the weight gain associated with TZDs

Notably, oral semaglutide [15] underwent evaluation at doses as high as 50 mgan increase of over threefold compared to the presently available 14 mg dosefor the management of type 2 diabetes