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or a growth that meets the ABCDE mnemonic criteria, which describes clinical signs of melanoma: A symmetry, B order i rregularity, C olor variation, D iameter, and E volving

It aggravates various cardiovascular (CV) risk factors and is, per se, an independent risk factor for CV mortality

The chemotherapeutic efficacy, especially in the parenteral use of high doses, is also based on this basis