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Nature 445 , 111115 (2007)

The hypothalamic-pituitary-adrenal (HPA) axis tightly regulates cortisol production through negative feedback mechanisms, and disruption at any level can result in pathological cortisol states requiring medical intervention

The results indicated that berberine was more concentrated in RBCs than in plasma and the maximum concentration of drug loading was 0.185 g/mL, while higher concentrations have been associated with hemolysis

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