It was initially believed that it acts through inhibition of cyclooxygenase enzymes, similar to non-steroidal anti-inflammatory drugs (NSAIDs)
Overexpression of these growth factors is associated with glaucoma, as it disrupts ECM turnover, leading to excessive ECM accumulation in the AH outflow pathway, increasing outflow resistence and ultimately resulting in elevated IOP, which contributes to glaucoma development (83, 84)
Treatment of malaria with these drugs can cause (severe) hemolysis in G6PD-deficient individuals (i.e., males having a variant G6PD or heterozygous females with skewed The Importance of Reduced Glutathione in Detoxification Click The Image Reduced Glutathione NADPH produced in the oxidative phase of the pentose phosphate shunt maintains the cysteinyl sulfur of glutathione in the reduced state
10.1164/rccm.200806-851OC Summary Keywords glutathione peroxidase, redox balance, oxidative stress, inflammation, iron death Citation Pei J, Pan X, Wei G and Hua Y (2023) Research progress of glutathione peroxidase family (GPX) in redoxidation