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Direct head-to-head data against tirzepatide showed CagriSema underperforming the highest tirzepatide dose at 84 weeks meaning monotherapy claims of comparable efficacy are not supported by current Phase 3 evidence

Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Peter Rossing, Naveed Sattar and Vikas Sridhar for their contribution to the peer review of this work

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