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In this essay, we shall look at what came before and the journey after 1912 (Figure 2) through clinical associations, recognition of the role of copper, the disease genetics, therapeutic developments, and eventually, the cloning of the gene harboring mutations, which led to mutation analysis and an increased understanding of the cellular mechanisms involved in copper metabolism

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A combination could therefore target metabolic dysfunction from two distinct and complementary angles, potentially leading to superior outcomes in weight management and glycemic control