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2.3% placebo) over 36 weeks [121]

Since 2015, large-scale cardiovascular outcome trials (CVOTs) have demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) significantly reduce the risk of major adverse cardiovascular events, cardiovascular mortality, and heart failure hospitalization in patients with T2DM and established cardiovascular disease or high-risk profiles

The regulator said anyone taking GLP-1 medicines should be alert to any signs of vision loss, stop taking the medicine and seek urgent medical attention if any changes were noted