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Researchers reported that MOTS-c administration significantly enhanced physical performance in mice across various ages, improving exercise tolerance in not just young but also middle-aged and old mice

Given the clinical evidence reviewed above, patients with type 2 diabetes and/or obesity are the most promising candidate population to benefit from GLP-1RA-centered pharmacotherapy to improve cardiovascular and kidney outcomes

In the body, GLP-1 helps support blood sugar regulation by prompting the pancreas to release insulin when appropriate, and it also plays a role in signals related to appetite and feeling full

First disclosed by Eli Lilly investigators in 2018 under the development code LY3298176, tirzepatide marked a deliberate departure from decades of incretin research that had focused almost exclusively on GLP-1 mono-agonism