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This hormone signals by binding to and activating GCGR, which is a G protein-coupled receptor primarily expressed by hepatocytes in the liver

It was produced primarily in enteroendocrine L-cells and released together with GLP-1 in response to food intake

These methodological limitations temper the strength of the conclusions and preclude a quantitative synthesis, highlighting the urgent need for prospective, dedicated ophthalmic RCTs

This reduction in systemic inflammation contributes to improved energy levels, better sleep quality, reduced joint pain, and the general sense of vitality that people report during months two and three