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These hepatic pathological alterations were associated with significantly elevated plasma IL-6 concentrations and TNF levels in both plasma and liver tissues (Fig

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Interestingly, removal of mSOD1 from motor neurons delayed the onset and early progression of disease, but did not affect the late progression phase [17, 18]

In vivo experiments using the DMM mouse model corroborated the in vitro results, demonstrating that OSR mitigates joint degeneration in an experimental setting that closely mimics osteoarthritic progression