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trials show that GLP-1 RAs decrease inflammatory markers, improve endothelial function, and decrease arterial stiffness

Regarding safety in real-world practice, these large observational studies have not identified unexpected safety signals beyond those known from clinical trials

Back De Herder, W, Klppel, G (28 July 2023) 'One hundred years after the discovery of insulin and glucagon: the history of tumors and hyperplasias that hypersecrete these hormones', Endocrine-Related Cancer , 30/9

It is indicated for the treatment and prevention of deep vein thrombosis and pulmonary embolism, including during pregnancy and following some surgeries