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"When weight is reduced through medical intervention, the hypothalamus seems to send new signals to areas of the brain that shape our likes and dislikes," says Dr Craven

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In real-world practice, those discontinuation rates may be even higher. Andrade said the medication could be helpful for people with severe obesity, who may still have trouble losing weight on the existing GLP-1 medications, although shed like to see more data on the side effects

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