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Mechanisms of action The cardiovascular benefits of SGLT2 inhibitors are likely mediated through multiple complementary pathways relevant to heart failure which include osmotic diuresis and natriuresis, which may reduce cardiac preload

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Meanwhile, GLP-1 receptor agonists liraglutide and semaglutide showed strong effects on restoring the imbalance of gut microbiota induced by PCOS, and these changes were closely associated with improvements in metabolic parameters

doi: 10.1210/jc.2012-3582 7 NtaliGAsimakopoulouASiamatrasTKomninosJVassiliadiDTzanelaMet al