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DNA Protonation at low ionic strength of solution

Although tacrolimus can cause kidney toxicity, dosing in patients with impaired kidney function must be carefully balanced

Nelson SD, Parker J, Lario R, Winnenburg R, Erlbaum MS, Lincoln MJ, Bodenreider O (2017) Interoperability of medication classification systems: lessons learned mapping established pharmacologic classes (EPCs) to SNOMED CT

TMAO levels are also modulated by kidney clearance, and impaired renal function leads to TMAO accumulation, further amplifying cardiovascular risk [4]