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The LCap and EE of ENZ loaded into SBA-15 MSN were determined based on our previous research [19]
Under physiological conditions, ROS are produced in a controlled manner by mitochondria, NOXs, and other enzyme systems, and are strictly regulated by antioxidant defenses [540,541,542]
Conversely, other studies have demonstrated that lactic acid may partially restore PGC-1 activity, reduce the expression of pro-inflammatory cytokines including TNF-, IL-1, and IL-6, alleviate renal injury, and improve survival in murine models of sepsis-induced AKI (Takakura and Zandi-Nejad, 2019)
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