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Understanding why fatigue occurs and how to manage it effectively can help patients optimise their treatment experience whilst maintaining therapeutic benefits

8 Although DPP-4 inhibitors have proven to be efficacious in reducing HbA 1C and improving beta-cell function, long-term clinical trial data are not yet available to assess the sustainability of glycemic control and protection of beta-cell mass

Given that the phase 3 clinical trial of resmetirom also had a long duration of 52 weeks, it is possible that more repeated dosing times are needed to improve fibrosis in WD-fed MC4R-KO mice