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[177], including twenty-two RCTs involving 1377 patients, a poor performance was observed for metformin when compared to other antidiabetic drugs such as the GLP-1 receptor agonist for hepatic fat content, the MASLD activity score, ALT, AST, GGT, and body weight

It also modulates reward pathways in the brain, reducing food cravings particularly for high-fat and high-sugar foods

The methionine pathway is one of the most crucial in the body as it involves the production of SAMe, the bodys major methyl donor

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