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Clarke and colleagues similarly noted that the majority of patients tolerated GLP-1RA therapy without requiring treatment cessation due to IBD-specific complications (96)

Moreover, LC administrated for 2 weeks suppresses atrogin-1 messenger RNA (mRNA) level in suspended rats hindlimb [35], and only 7 days of LC administration downregulates MuRF-1 and atrogin-1 mRNAs reducing muscle wasting in a rat model of cancer cachexia [32]

A 2025 meta-analysis supported some of these claims, finding that collagen peptide supplementation may improve bone mineral density and muscle function

doi: 10.1038/s41598-017-01732-1 80 ConnellyPJPrenticeNPCouslandGBonhamJ