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It mimics GH's lipolytic effects, promoting fat breakdown and inhibiting new fat formation, while early research suggests it preferentially acts on adipose tissue without significantly affecting IGF-1 or systemic GH levels

In diabetes mellitus, oxidative stress plays a pivotal role in the development and progression of diabetic complications [14]

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Subsequently, the obtained solution was extruded through a 0.05 m pore size membrane (FPB005A12, Membrane Solutions, Shanghai, China) and mixed with si-PGC-1 prepared in 30% ethanol and 50 mM citric acid (pH 4) to achieve a total lipid:siRNA ratio of approximately 7:1 (by weight)