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Under carefully engineered pharmacologic conditions, it may become a complementary metabolic signal that helps transform incretin therapy from appetite suppression alone into a more comprehensive strategy targeting appetite, substrate oxidation, hepatic metabolism, and energy expenditure

A meta-analysis showing that therapy with GLP-1 RA in people with T2DM lowers all cause mortality and protects against macrovascular and microvascular complications

Timing considerations can also prove helpful

Additionally, Wegovy can delay gastric emptying, which may theoretically affect the absorption of some oral medications, although this is not specifically noted as a concern with sertraline in clinical guidance