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Mitochondrial dysfunction and metabolic reprogramming induce macrophage pro-inflammatory phenotype switch and atherosclerosis progression in aging

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Why Supplemental Testosterone (TRT) Alone May Increase Estrogen When men with excess fat use TRT, testosterone levels do risebut a portion of that testosterone is rapidly converted to estrogen by aromatase in fat tissue

Additionally, overexpression of CHAC1 can enhance the sensitivity of tumor cells to chemotherapy by reducing intracellular GSH levels, thereby increasing oxidative stress and promoting cell death