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While these results require replication, they suggest DSIP may support recovery from substance dependence

Recently, McDonald and colleagues revealed that frequent mistranslation events involving a shift from serine to either proline or arginine have distinct effects: serineto-proline substitution reduces the ability of polypeptide chains to bind HSP70s, whereas serineto-arginine substitution prevents misfolded nascent proteins from being denatured and degraded (McDonald et al., 2025)

For comfort and compliance it would be highly desirable to have effective alternative means to administer peptides, such as by the oral route

Despite the importance of TJs in cellcell adhesion, it is the more basal desmosome structures that are primarily responsible for the mechanical strength of the intestinal epithelium by acting as spot-welds that clutch cells together (Roxas and Viswanathan 2018)