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Most sleep-related reports occur during dose escalation phases rather than at stable maintenance doses

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Another cost-effectiveness analysis published in JMCP found that tirzepatide 15 mg produced greater quality-adjusted life-years (QALYs) and delayed progression to insulin, with incremental cost-effectiveness ratios (ICERs) of about USD 54,700/QALY (15 mg) and USD 70,100/QALY (10 mg) vs semaglutide 2.0 mg

For example, the iodothyronine deiodinase enzymes (which convert T4 to T3) and glutathione peroxidase enzymes (which protect the thyroid from hydrogen peroxide-induced damage during thyroid hormone synthesis) all require selenium