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By overcoming the low oral bioavailability challenges of peptide GLP-1 RAs, Orforglipron represents a disruptive innovation that could reshape the treatment paradigm for type 2 diabetes

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"For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM, that explain poor responders to their medications." Although the biological mechanism remains unclear, Gloyn believes the answer is likely complex and influenced by multiple factors